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PDE5 inhibitors, including Sildenafil (Viagra), Tadalafil (Cialis), Vardenafil (Zhewitra), and Avanafil (Stendra), all work on a similar principle. They block the enzyme phosphodiesterase type 5, which leads to increased levels of cyclic GMP in the *****. This, in turn, relaxes the smooth muscles and enhances blood flow, aiding in an erection when *****ly aroused. Despite their common mechanism, these medications differ in onset times, duration of effect, and side effect profiles.

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