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Percocet is a prescription medication that combines oxycodone, an opioid pain reliever, with acetaminophen, a non-opioid analgesic. This powerful combination makes Percocet effective for managing moderate to severe pain.Percocet is a prescription medication that combines oxycodone and acetaminophen, and is commonly prescribed to manage moderate to severe pain. Its effectiveness has made it a popular choice among patients recovering from surgery, injuries, or dealing with chronic pain.