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 Malegra Oral Jelly, like other medications containing sildenafil citrate (the same active ingredient found in Viagra), can potentially cause priapism—a prolonged, painful erection that lasts for more than four hours. While priapism is rare, it is a serious side effect and should be addressed immediately to prevent permanent damage to the *****. Why Does Malegra Oral Jelly (and similar medications) Carry a Risk of Priapism? Mechanism of Action: Sildenafil Citrate works by inhibiting phosphodiesterase type 5 (PDE5), an enzyme that breaks down cyclic GMP, a molecule that relaxes the smooth muscles in the blood vessels of the *****. This relaxation allows more blood to flow into the *****, helping to achieve and maintain an erection. Normally, after ***** arousal ends, blood flow to the ***** decreases, and the erection subsides. However, in rare cases, sildenafil citrate can cause an excessive build-up of cyclic GMP in the penile tissue, leading to prolonged vasodilation (dilated blood vessels), which results in sustained blood flow and a prolonged erection. Imbalance in Blood Flow Regulation: Sildenafil helps increase blood flow, but in some cases, the regulation of blood flow can become imbalanced, leading to a trapped blood flow in the *****. If blood is trapped and unable to drain properly, the result can be a prolonged erection, known as priapism. Pre-existing Conditions: Certain underlying health conditions or risk factors can increase the likelihood of priapism when using medications like Malegra Oral Jelly. These conditions include: Sickle cell anemia or other blood disorders (e.g., leukemia, thalassemia) Peyronie's disease (which causes abnormal curvature of the *****) Multiple myeloma History of priapism in the past Use of other medications that affect blood flow or blood cell count, such as anticoagulants or certain antidepressants Excessive or Incorrect Dosage: Taking a higher-than-recommended dose of Malegra Oral Jelly or using it more frequently than prescribed can increase the risk of side effects, including priapism. It's important to follow the prescribed dosage and usage instructions carefully to minimize the risk. Alcohol or Drug Interaction: Excessive alcohol consumption or the use of certain recreational drugs in combination with sildenafil can also heighten the risk of priapism. Alcohol can interfere with the body’s ability to regulate blood flow, while some drugs (especially those that alter blood pressure or blood flow) can interact with sildenafil and exacerbate the risk. What to Do if Priapism Occurs: Seek immediate medical attention if you experience an erection that lasts longer than 4 hours, especially if it becomes painful. Priapism can cause permanent damage to the erectile tissue of the ***** if left untreated, potentially leading to permanent erectile dysfunction.

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